Antons Sizovs

  Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

 Education and experience

 2006 B.S. in Chemistry, University of Latvia, Latvia.

 2002-2006 Research Assistant under the guidance of Dr. Chem. Einars Loza, Latvian Institute of Organic   Synthesis, Latvia.


 

Current research interests

- development of functional magnetic resonance imaging (MRI) contrast agents for dopamine transporter imaging – a marker for several neurological diseases (e.g. Parkinson disease). The work involves design and synthesis of tropane-based chelators of gadolinium (III) ions, their evaluation as T1 relaxivity agents, and ability to penetrate the blood-brain barrier. The end goal is to develop compounds that can enhance the contrast of regions of the brain containing dopamine transporter by MRI.

- development of trehalose-based gene and drug delivery vectors  aimed to be stable toward aggregation in serum and blood and have high specificity for targeted cells.