Publications

PEER-REVIEWED PUBLICATIONS

P. M. McLendon, D. J. Buckwalter, E. M. Davis, T. M. Reineke "Interaction of Poly(glycoamidoamine) DNA Delivery Vehicles with Cell-Surface Glycosaminoglycans Leads to Polyplex Internalization in a Manner Not Solely Dependent on Charge" Molecular Pharmaceutics, 2010, In Press.

P. M. McLendon, K. Fichter, T. M. Reineke, "Poly(glycoamidoamine) Vehicles Promote pDNA Uptake Through Multiple Routes and Efficient Gene Expression via Caveolae-Mediated Endocytosis" Molecular Pharmaceutics, 2010, 7, 738-750. 

A. Sizovs, P. M. McLendon, S. Srinivasachari, T. M. Reineke, "Carbohydrate Polymers for Nonviral Nucleic Acid Delivery" Topics in Current Chemistry - Nucleic Acid Transfection, Springer 2010, In Press. 

C. -C. Lee, G. Grandinetti, P. M. McLendon, T. M. Reineke "A Polycation Scaffold Presenting Tunable "Click" site: Conjugation to Carbohydrate Ligands and Examination of Hepatocyte-Targeted pDNA Delivery" Macromolecular Bioscience 2010, 10, 585-598. 

Y. Liu and T. M. Reineke "Degradation of Poly(glycoamidoamine) DNA Delivery Vehicles: Polyamide Hydrolysis at Physiological Conditions Promotes DNA Release", Biomacromolecules, 2010, 11, 316-325.

L. E. Prevette, M. Lynch, T. M. Reineke "Amide Spacing Influences pDNA Binding of Poly(amidoamine)s" Biomacromolecules, 2010, 11, 326-332.

J. M. Bryson, K. M. Fichter, W.-J. Chu, J.-H. Lee, J. Li, P. M. McLendon, L. A. Madsen, T. M. Reineke, “Polymer Beacons for Luminescence and Magnetic Resonance Imaging of DNA Delivery” Proc. Nat. Acad. Sci. USA, 2009 , 106, 16913-16918.

S. Srinivasachari, T. M. Reineke, “Versatile Supramolecular pDNA Vehicles via “Click Polymerization” of Beta-Cyclodextrin with Oligoethyleneamines” Biomaterials, 2009, 30, 928-938.

V. Taori, Y. Liu, T. M. Reineke “DNA delivery in vitro via surface release from multilayer assemblies with poly(glycoamidoamine)s” Acta Biomaterialia, 2009, 5, 925-933

J. Bryson, W. –J. Chu, J. –H. Lee, T. M. Reineke, “A Beta-Cyclodextrin “Click Cluster” Decorated with Seven Paramagnetic Chelates Containing Two Water Exchange Sites" Bioconjugate Chem. 2008, 19, 1505-1509.

L. E. Prevette, K. Kizjakina, M. Lynch, T. M. Reineke, “Correlation of Amine Number and DNA Binding Mechanism for Trehalose-based Polyamides” Langmuir 2008, 24, 8090-8101.

S. Srinivasachari, K. M. Fichter, T. M. Reineke, “Polycationic Beta-Cyclodextrin “Click Clusters”: Monodisperse and Versatile Scaffolds for Nucleic Acid Delivery”, J. Am. Chem. Soc. 2008, 130, 4618-4627.

C. –C. Lee, Y. Liu, and T. M. Reineke, “A General Structure-Bioactivity Relationship for Poly(glycoamidoamines)s: Amine Density and Branching Affects Cytotoxicity and pDNA Delivery Efficiency”, Bioconjugate Chem. 2008, 19, 428-440.

C. Gulgas, T. M. Reineke, “Macrocyclic Eu3+ Chelates Show Selective Luminescent Responses to Anions” Inorg. Chem. 2008, 47, 1548-1559.

R. Lucas, M. Benjamin, T. M. Reineke, “Comparison of a Tartaric Acid Derived Polymeric MRI Contrast Agent to a Small Molecule Model Chelate” Bioconjugate Chem. 2008, 19, 24-27.

K. M. Fichter, L. Zhang, K. L. Kiick, and T. M. Reineke “Peptide-Functionalized Poly(ethylene glycol) Star Polymers: DNA Delivery Vehicles with Multivalent Molecular Architecture”, Bioconjugate Chem. 2008, 19, 76-88.

L. Prevette, T. Krodger, T. M. Reineke, M. L. Lynch, "Deciphering the Role of Hydrogen Bonding In Enhancing DNA-Polycation Interactions" Langmuir 2007, 23, 9773-9784.

S. Srinivasachari, Y. Liu, L. E. Prevette, and T. M. Reineke “Trehalose Click Polymers for pDNA Delivery: Degree of Polymerization Affects Polyplex Stability and Delivery Efficacy”, Biomaterials 2007 28, 2885-2898.

Y. Liu, T. M. Reineke, “Poly(glycoamidoamine)s for Gene Delivery. Structural Effects on Cellular Internalization, Buffering Capacity, and Gene Expression” Bioconjugate Chem. 2007 18, 19-30.

T. M. Reineke “PGAAs: Cationic Glycopolymers for DNA Delivery” J. Polym. Sci. A: Polym. Chem. 2006, 44, 6895-6908.

S. Srinivasachari, Y. Liu, G. Zhang, L. Prevette, T. M. Reineke, “Trehalose Click Polymers Inhibit Nanoparticle Aggregation and Promote pDNA Delivery in Serum” J. Am. Chem. Soc. 2006 128, 8172-8184.

Y. Liu, T. M. Reineke, “Poly(glycoamidoamine)s for Gene Delivery. Stability of Polyplexes and Efficacy with Cardiomyoblast Cells” Bioconjugate Chem. 2006, 17, 101-108.

Y. Liu, L. Wenning, M. Lynch, T. M. Reineke, “Gene Delivery with Novel Poly(L-tartaraminoamine)s” Polymeric Drug Delivery Volume I - Particulate Drug Carriers, Svenson, S. (Ed.), ACS Symposium Series, Vol. 923, American Chemical Society, Washington, DC, 2006, 217-227.

C. Gulgas, T. M. Reineke, “Synthesis, Characterization, and Luminescence Properties of a New Series of Eu3+ - Containing Macrocycles” Inorg. Chem. 2005, 44, 9829-9836.

T. M. Reineke and M. W. Grinstaff “Designer Materials for Nucleic Acid Delivery” MRS Bulletin, 2005 30, 635-639.

Y. Liu, T. M. Reineke, “Hydroxyl Stereochemistry and Amine Number within Poly(glycoamidoamine)s Affect Intracellular DNA Delivery” J. Am. Chem. Soc. 2005, 127, 3004-3015.

Y. Liu, L. Wenning, M. Lynch, and T. M. Reineke, “New Poly(D-glucaramidoamine)s Induce DNA Nanoparticle Formation and Efficient Gene Delivery into Mammalian Cells” J. Am. Chem. Soc. 2004 126, 7422-7423.

M. E. Davis, S. H. Pun, N. C. Bellocq, T. M. Reineke, S. R. Popeilarski, S. Mishra, J. D. Heidel, “Self-Assembling Nucleic Acid Delivery Vehicles via Linear, Water-Soluble, Cyclodextrin-Containing Polymers” Current Med. Chem., 2004, 11, 179-197.

T. M. Reineke and M. E. Davis, “Structural Effects of Carbohydrate-Containing Polycations on Gene Delivery 1: Carbohydrate Size and Its Distance from Charge Centers” Bioconjugate Chem. 2003, 14, 247-254.

T. M. Reineke and M. E. Davis, “Structural Effects of Carbohydrate-Containing Polycations on Gene Delivery 2: Charge Center Type” Bioconjugate Chem. 2003, 14, 255-261.

T. M. Reineke and M. E. Davis, "The Effects of Charge Separation in Quaternary, Ammonium, DABCO-Containing Polymers on In Vitro Toxicity and Gene Delivery" Mat. Res. Soc. Symp. Proc., 2002, 724, N10.2.1-N10.2.6.

J. Kim, B. Chen, T. M. Reineke, H. Li, M. Eddaoudi, D. B. Moler, M. O’Keeffe, O. M. Yaghi, "The Assembly of Metal-Organic Frameworks from Large Organic and Inorganic Secondary Building Units: New Examples and Simplifying Principles for Complex Structures" J. Am. Chem. Soc., 2001, 123, 8239-8247.

M. Eddaoudi, D. B. Moler, H. Li, T. M. Reineke, B. L. Chen, M. O’Keeffe, O. M. Yaghi, "Modular Chemistry: Secondary Building Units as a Basis for the Design of Highly Porous and Robust Metal-Organic Frameworks", Acc. Chem. Res., 2001, 34, 319.

B. L. Chen, M. Eddaoudi, T. M. Reineke, J. W. Kampf, M. O’Keeffe, O. M. Yaghi, "Cu2(ATC)•6H2O: Design of Open Metal Sites in Porous Metal-Organic Crystals (ATC: 1,3,5,7-Adamantane Tetracarboxylate)", J. Am. Chem. Soc., 2000, 122, 11559-11560.

T. M. Reineke, M. Eddaoudi, D. Moler, M. O’Keeffe, O. M. Yaghi, "Large Free Volume in Maximally Interpenetrating Networks: The Role of Secondary Building Units Exemplified by Tb2(ADB)3[(CH3)2SO]4•16[(CH3)2SO]", J. Am. Chem. Soc., 2000, 122, 4843-4844.

M. O'Keeffe, M. Eddaoudi, H. Li, T. Reineke, O. M. Yaghi, "Frameworks for Extended Solids: Geometrical Design Principals", J. Solid State Chem., 2000, 152, 3-20.

T. M. Reineke, M. Eddaoudi, M. O’Keeffe, O. M. Yaghi, "A Microporous Lanthanide-Organic Framework", Angew. Chem., Int. Ed. Engl., 1999, 38, 2590-2594.

T. M. Reineke, M. Eddaoudi, M. Fehr, D. Kelley, O. M. Yaghi, "From Condensed Lanthanide Coordination Solids to Microporous Frameworks Having Accessible Metal Sites", J. Am. Chem. Soc., 1999, 121,1651-1657.

M. Eddaoudi, H. Li, T. Reineke, M. Fehr, D. Kelley, T.L. Groy, O. M. Yaghi, "Design and Synthesis of Metal-Organic Frameworks With Permanent Microporosity", Topics in Catalysis, 1999, 9, 105-111.

C. L. Muller, J. R. Bever, M. A. Dordel, M. M. Kitabwalla, T. M. Reineke, J. B. Sausker, T. R. Seehafer, Y. Li, J. P. Jasinski, "Regiochemistry of Intramolecular Photocycloaddition of 1,3-Dioxin-4-ones Tethered Through the Ketal Carbon", Tetrahedron Lett. 1997, 38, 8663-8666.

PUBLISHED PREPRINTS

J. M. Bryson, K. M. Fichter, P. M. McLendon, T. M. Reineke, “Tracking nucleic acid delivery with lanthanide containing polymers” Polymer Preprints 2009, 50(1).

P. M. McLendon, E. M. Davis, T. M. Reineke, “Understanding the role of glycosaminoglycans in cell surface binding of poly(glycoamidoamine) DNA delivery vectors” Polymer Preprints 2009, 50(1).

P. M. McLendon, K. M. Fichter, T. M. Reineke, “Poly(glycoamidoamine) DNA delivery vectors are internalized by multiple endocytic pathways” Polymer Preprints 2009, 50(1).

J. Bryson, K. M. Fichter, T. M. Reineke, “Lanthanide-containing polymers as nucleic acid delivery vectors” Polymer Preprints 2008, 49, 257.

C. –C. Lee, G. Grandinetti, T. M. Reineke, “Synthesis and characterization of liver-targeted polymers as DNA delivery vectors” Poly. Mat. Sci. Eng. 2008, 98 504.

Y. Liu, S. Srinivasachari, R. Lucas, M. Benjamin, T. M. Reineke, “DNA delivery and diagnostic imaging with glycopolymers” Poly. Mat. Sci. Eng. 2008, 98 305.

G. Grandinetti, T. M. Reineke, “Mitochondrial permeability transition pore effects in apoptosis induced by polycationic polymer gene delivery vectors” Poly. Mat. Sci. Eng. 2008, 99, 419.

Y. Liu, K. Fichter, J. Gulick, J. Robbins, T. M. Reineke, “Glycopolymers for DNA Delivery to Cardiomyocytes” Poly. Mat. Sci. Eng. 2007, 96, 327.

K. Kizjakina and T. M. Reineke “Effects of Secondary Amine Number in Trehalose Click Polymers for Transfection” Poly. Mat. Sci. Eng. 2007, 96, 646.

P. M. McLendon and T. M. Reineke, “Exploring Cellular Internalization Mechanisms of Polymeric Gene Delivery Vectors” Poly. Mat. Sci. Eng. 2007, 96, 650-651.

C. –C. Lee and T. M. Reineke, “Biological Effect of Amine Density Within Poly(glycoamidoamine) DNA Delivery Vehicles” Poly. Mat. Sci. Eng. 2007, 96, 586.

J. M. Bryson and T. M. Reineke, “Gadolinium-Containing Glyco-polymers for MRI” Poly. Mat. Sci. Eng. 2007, 96, 658.

V. P. Taori and T. M. Reineke, “Effects of Molecular Weight on Poly(Galactaramidoamine) Toxicity and DNA Delivery” Poly. Mat. Sci. Eng. 2007, 96, 643.

L. E. Prevette, M. L. Lynch, T. M. Reineke, “Understanding DNA Binding Mechanisms of Trehalose-Based Polymeric Gene Delivery Vectors” Poly. Mat. Sci. Eng. 2007, 96, 843-844.

Y. Liu, K. Fichter, J. Gulick, J. Robbins, T. M. Reineke, “Glycopolymers for DNA Delivery to Cardiomyocytes” Poly. Mat. Sci. Eng. 2006, 96, 327.

M. Benjamin, T. M. Reineke, “Synthetic Design of Glycopolymers Containing Gadolinium Chelates as MRI Contrast Agents” Poly. Mat. Sci. Eng. 2006, 94, 134-135.

C.-C. Lee, T. M. Reineke, “The Effects of Amine Number within Poly(glycoamidoamine) DNA Delivery Vectors” Poly. Mat. Sci. Eng. 2006, 94, 345.

L. E. Prevette, M. Lynch, T. M. Reineke, “Deciphering the Mechanism of Poly(glycoamidoamine)-DNA Interactions” Poly. Mat. Sci. Eng. 2006, 94, 356-357.

K. Fichter, T. M. Reineke, “Quantification of the Intracellular pH environment of oligonucleotides delivered with poly(glycoamidoamine)s” Poly. Mat. Sci. Eng. 2006, 94, 503-504.

Y. Liu, S. He, W. K. Jones, T. M. Reineke, “Poly(glycoamidoamine)s for DNA Delivery to Myocardial Cells” Poly. Mat. Sci. Eng. 2006, 94, 352-353

S. Srinivasachari, G. Zhang, Y. Liu, T. M. Reineke, “Novel “Click” Glycopolymers Containing 1,2,3 Triazole Linkers for DNA Delivery” Poly. Mat. Sci. Eng. 2006, 94, 180-181.

V. Taori, T. M. Reineke, “Biological Affect of Amine Spacing Within Poly(glycoamidoamine) DNA Delivery Vectors” Poly. Mat. Sci. Eng. 2006, 94, 445.

Y. Liu, T. M. Reineke, “Spermine Based poly(glycoamidoamine)s as DNA Delivery Vectors” Polymer Preprints 2005, 46, 704.

C.-C. Lee, L. E. Prevette, M. Lynch, T. M. Reineke, “Synthesis and physical characterization of novel biodegradable polyesters for nucleic acid delivery” Polymer Preprints 2005, 46, 335.

T. M. Reineke, Y. Liu, “New poly(glycoamidoamine)s promote DNA nanoparticle formation and efficient intracellular gene delivery” Polymer Preprints 2005, 46, 66-67.

G. Zhang, S. Srinivasachari, T. M. Reineke, “A new b-cyclodextrin/oligoamine dendrimer for DNA delivery” Polymer Preprints, 2005, 46, 1.

Y. Liu, T. M. Reineke, “Structural traits of poly(glycoamidoamine)s affect DNA delivery” Poly. Mat. Sci. Eng. 2005, 92, 659-660.

S. Srinivasachari, T. M. Reineke, “New dendritic beta-cyclodextrin/triazole system for DNA delivery” Poly. Mat. Sci. Eng. 2005, 92, 654-655.

Yemin Liu and T. M. Reineke, “Synthesis and Characterization of Polyhydroxylamides for Gene Delivery” Poly. Mat. Sci. Eng. 2003, 89, 53-54.

T. M. Reineke and M. E. Davis, “Structure-Property Investigation of Trehalose and Beta-Cyclodextrin-Containing Polycations for Gene Delivery” Poly. Mat. Sci. Eng. 2003, 88, 224-225.